Conclusion: Fulvic acid shows anti-fungal properties.
Title: Carbohydrate derived fulvic acid: an in vitro investigation of a novel membrane active antiseptic agent against Candida albicans biofilms
Type of Document: Peer-reviewed journal article
Takeaway: The aim of this study was to evaluate the antifungal activity of carbohydrate-derived fulvic acid (CHD-FA) against Candida albicans, and to characterize its mode of action. CHD-FA was active against planktonic and sessile C.albicans at concentrations 0.125 and 0.25% respectively, and was shown to be fungicidal, acting through disruption of the cell membrane activity. Overall, based on the promising in vitro spectrum of activity and minimal biofilm resistance of the natural and cheap antiseptic CHD-FA, further studies are required to determine its applicability for clinical use.
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2012.00116/full
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Conclusion: Carbohydrate-derived fulvic acid has antimicrobial properties against several bacteria and fungi.
Title: Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections
Type of Document: Technical Report
Takeaway: We completed the objectives in specific aim 1 of the award statement of work by determining the in vitro susceptibility of CHD-FA against a collection of multi-drug resistant Acinetobacter baumanii, Pseudomonas aeruginosa, carbapenamase-resistant Klebsiella pneumoniae, Enterococcus faecium, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Enterobacter spp., other clinically important species as well as azole resistant fungal pathogens Candida spp., Aspergillus fumigatus and polyene-resistant non-fumigatus Aspergillus species, Fusarium species and Zygomycetes. Most bacteria show complete growth inhibition at 0.06 – 0.125% fulvic acid, while efficacy with fungi is 0.125-0.5%.
Link: https://apps.dtic.mil/sti/citations/AD1006071
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Conclusion: Fulvic acid has antibacterial and antifungal properties.
Title: New strategic insights into managing fungal biofilms
Type of Document: Review article
Takeaway: Oxifulvic acid, a derivate of fulvic acid, has been shown to elicit antibacterial and antifungal properties. However, these formulations contain numerous toxic elements that make their use clinically impossible. Recently, there has been the development of a pure form of fulvic acid, carbohydrate derived fulvic acid (CHD-FA), that has been shown to be safe to use clinically and absent from environmental
contaminants known to be harmful to the host.
Link: https://sci-hub.se/10.3389/fmicb.2015.01077
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Conclusion: Fulvic acid can be used to treat bacterial infections, including those caused by antibiotic-resistant bacteria.
Title: Fulvic acid and antibiotic combination
Type of Document: Patent
Takeaway: This invention relates to a fulvic acid and antibiotic combination for use in the treatment of various diseases and conditions. The invention further relates to the use of the combination for the treatment of various diseases and conditions, including bacterial infection. In particular, the bacteria are antibiotic resistant bacteria.
Link: https://patents.google.com/patent/EP2317998A1/en
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Conclusion: Fulvic acid has antiviral, antifungal, antioxidant, and antibiotic properties.
Title: Natural products as antifungals
Type of Document: Book chapter
Takeaway: Kurobane et al. (1981) reported that Penicillium brefeldianum produces fulvic acid. This compound is found to exhibit antiviral, antifungal, antioxidant, and antibiotic activities.
Link: https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/B9780128158241000044
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Conclusion: Fulvic acids have antifungal and antibacterial properties.
Title: Preparation and investigation of fulvic acid and its metal derivative complexes with application
Type of Document: Peer-reviewed journal article
Takeaway: The antimicrobial activity test revealed that fulvic acid-metal complexes recorded an activity against Candida albicans fungi. In contrary, it was found that most compounds exhibit antibacterial activity against the other tested types of microbes, including Escherichia coli and Streptococcus pneumoniae.
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Conclusion: Fulvic acid can be used to treat infections caused by multidrug resistant bacteria.
Title: Fulvic acid and antibiotic combination for the inhibition or treatment of multi-drug resistant bacteria
Type of Document: Patent
Takeaway: Fulvic acid as the active ingredient is used in the treatment or inhibition of multi-drug resistant bacteria, in particular NDM-1 bacteria producing carbapenemase or extended-spectrum β-lactamase (ES8L) resistant bacteria. The multi-drug resistant bacteria may be gram negative bacteria including, but not limited to, Klebsiella pneumoniae or Escherichia coli. The fulvic acid can be provided in combination with one or more antibiotics from the class of carbapenems or polymyxin antibiotics.
Link: https://patentscope.wipo.int/search/en/detail.jsf?docId=US130253547
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Conclusion: Fulvic acid has antibacterial properties.
Title: Bacteriostatic and bactericidal composition
Type of Document: Patent
Takeaway: A composition which has bactericidal or bacteriostatic properties comprises coal-derived fulvic acid or a salt or a derivative thereof as active ingredient in a suitable carrier. The carrier is preferably water.
Link: https://patents.google.com/patent/GB2244215A/en
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Conclusion: Fulvic acid can be used to treat fungal infections.
Title: Fulvic acid in combination with fluconazole or amphotericin B for the treatment of fungal infections
Type of Document: Patent
Takeaway: A combination of fulvic acid or a salt, ester, or derivative thereof and an antifungal compound selected from fluconazole and amphotericin B for use in the treatment or prophylaxis of a disease or condition of the human or animal body is described. The fulvic acid can be carbohydrate-derived fulvic acid (CHD-FA).
Link: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2010082182
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Conclusion: Humic acid has antibacterial properties.
Title: Composition having bactericidal or bacteriostatic activity
Type of Document: Patent
Takeaway: A composition which has bactericidal or bacteriostatic properties which comprises humic acid or a salt or a derivative thereof as active ingredient in a suitable carrier. The active ingredient is preferably an alkali metal salt of humic acid and the carrier is preferably water.
Link: https://patents.google.com/patent/US4999202A/en?oq=US4999202