Conclusion: Humic acids can stimulate the immune system in various ways.
Title: Glucan and Humic Acid: Synergistic Effects on the Immune System
Type of Document: Peer-reviewed journal article
Takeaway: We decided to evaluate the immunological effects of two different types of humic acids, differing in source and biochemical characteristics. Using both components either alone or in combination with the well-established yeast-derived immunomodulator glucan, we measured their effects on both the cellular (phagocytosis and tumor suppression) and humoral (antibody production and cytokine secretion) branches of immune reactions. In summary, our results suggest that humic acids are biologically active immunodulators
affecting both the humoral and cellular branches of immune reactions. In addition, the two humic acids studied
here are working in synergy in stimulation of the immune reaction, supporting further studies of these natural immunomodulators
Link: https://sci-hub.hkvisa.net/10.1089/jmf.2009.0178
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Conclusion: Fulvic acid reduces the activity of human immune cells involved in causing allergy.
Title: Microarray analysis of immediate-type allergy in KU812 cells in response to fulvic acid
Type of Document: Peer-reviewed journal article
Takeaway: Fulvic acid extracted from solubilized excess sludge (SS-FA) affected the expression of human genes that were involved in the following pathways: signal transduction, cytokine-cytokine receptor interaction, immune response, cell adhesion molecules and IgE receptor β subunit response.
Link: https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/21331654/
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Conclusion: Fulvic acid reduces inflammation caused by the stimulation of the human immune cells called monocytes.
Title: Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes
Type of Document: Peer-reviewed journal article
Takeaway: In conclusion, fulvic acid (FA) inhibited the expression of COX-2 and production of PGE2 from homocysteine-induced monocytes. Stimulation of homocysteine in monocytes resulted in increased phosphorylation of ERK and JNK, and activation of NF-κB. FA inhibited homocysteine-induced inflammatory mediator expression by regulating the activation of these pathways.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369892/
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Conclusion: Humic acid stimulated the germ-killing immune response of the human immune cells called mononuclear cells.
Title: Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat
Type of Document: Peer-reviewed journal article
Takeaway: The studied humic acid (HA) sample stimulates the production of proinflammatory cytokines IL-12,
TNFα, IL-1β, and IFNγ by human mononuclear cells. In human peripheral blood mononuclear cells, it was shown that the studied HA sample also significantly enhanced the secretion of the main cytokines typical of the Th1-type polarization of the immune response, which works against pathogenic invasion. Production of IL-12 increased by 8.3 times, TNFα by 93.6 times, IFNγ by 170 times relative to the control.
Link: https://sci-hub.se/https://link.springer.com/article/10.1007/s10517-021-05088-5
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Conclusion: Humic acid has immunomodulatory effects on the human immune cells called macrophages.
Title: Bimodal effect of humic acids on the LPS-induced TNF-α release from differentiated U937 cells
Type of Document: Peer-reviewed journal article
Takeaway: The results demonstrate a concentration-dependent bimodal effect of humic acid (HA) on the TNF-alpa release of differentiated LPS-stimulated U937 cells (which are human macrophage-like cells) for both the natural black peat HA from the Altteich peatland and the HA-like polymer KOP. Low HA concentrations (10–80 microg/ml) enhanced the TNF-alpha release by up to threefold (pro-inflammatory activity), while HA concentrations >100 microg/ml reduced it about 10-fold (anti-inflammatory activity). Fulvic acid (FA) failed to enhance TNF-alpha release, but reduced it at higher concentrations (>200 microg/ml) by the half. Brown water HA did not exert any significant effect on TNF-a release.
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Conclusion: Fulvic acid-containing beverages promote health by preventing and treating gastrointestinal diseases, preventing tumors, improving the immunity of a human body, reducing blood glucose and blood fat, improving the appetite and sleep.
Title: Natural fulvic acid compound health-care beverage as well as preparation method thereof
Type of Document: Patent
Takeaway: The invention discloses a natural fulvic acid compound health-care beverage as well as a preparation method thereof. The compound health-care beverage is prepared by mixing one or more of edible-grade natural fulvic acid, extracts of traditional Chinese medicine, a sweetening agent, an acidulant or a stabilizer with water. The beverage comprises the following components in percentage by weight: 0.1-0.6% of edible-grade natural fulvic acid, 0.05-0.2% of the extracts of traditional Chinese medicine, 2-6% of the sweetening agent, 0.01-0.5% of the acidulant, 0.01-0.15% of the stabilizer and the balance being water. The beverage disclosed by the invention is abundant in raw material source and simple in preparation method. Medical functions of the natural fulvic acid are applied to daily beverages, so that the beverage is coffee in luster, unique in flavor, palatable in sweetness and sourness, and free from medicine taste, preservatives or pigments. The beverage has health-care functions of preventing and treating gastrointestinal diseases, preventing tumors, improving the immunity of a human body, reducing blood glucose and blood fat, improving the appetite and sleep and the like and is free from side effect when being drunk for a long time, so that the beverage is an ideal health-care beverage.
Link: https://patents.google.com/patent/CN103564587B/en?q=fulvic+acid&oq=fulvic+acid&page=4
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Conclusion: Fulvic acid can help reduce the side effects of alcohol drinking.
Title: Fulvic acid health-care product with sober-up and anti-drunk function
Type of Document: Patent
Takeaway: The invention provides a fulvic acid health-care product with the sober-up and anti-drunk function. The health-care product is oral liquid which is characterized by comprising the following components by weight percent: 1-10 percent of fulvic acid, 5-30 percent of sugar and the balance of water. The invention obviously fastens metabolism of alcohol in human blood, increases the tolerance for human body to alcohol, shortens the drunk time and has favorable sober-up and anti-drunk function. The fulvic acid health-care product is a safe and reliable natural product and can satisfy the needs of people.
Link: https://patents.google.com/patent/CN101721425A/en?q=fulvic+acid+health&oq=fulvic+acid+health
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Conclusion: Fulvic acid-containing composition reduces hair loss and promotes hair growth.
Title: Composition for preventing hair loss and the preparation method thereof
Type of Document: Patent
Takeaway: The present invention is a composition related to hair loss prevention and hair growth promoting composition using natural materials. Specifically, the present invention is an active ingredient, sheep, bovine, goat of colostrum, beta glucan extracted from yeast (Beta Glucan), peat soil extracted from fulvic acid ( Fulvic Acid), fruit from Amazon, Caffeine guarana extracted from Guarana and Eucalyptus tree extract are the main ingredients, and are composed of colostrum and beta glucan as main ingredients. The composition consists of a scalp coating agent consisting of acid and natural caffeine and eucalyptus extract as a main component, and relates to a hair loss prevention and hair growth promoting composition that can achieve more effective hair loss prevention and hair growth promoting effect by using them in parallel.
Link: https://patents.google.com/patent/KR101274583B1/en?q=fulvic+acid+health&oq=fulvic+acid+health&page=9
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Conclusion: Shilajit may strengthen the immune system.
Title: Mast cell protecting effects of shilajit and its constituents
Type of Document: Peer-reviewed journal article
Takeaway: Shilajit (100 ug/mL) and a combination of its constituents MCB, DDP, and fulvic acids significantly protected the mesenteric mast cells of rats against antigen-induced degranulation.
Link: https://sci-hub.hkvisa.net/10.1002/ptr.2650030606
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Conclusion: Fulvic acid promotes hair growth.
Title: Compositions and methods for human use containing fulvic acid
Type of Document: Patent
Takeaway: The present invention provides compositions comprising fulvic acid. The present invention further provides methods and compositions for promoting hair growth involving the use of fulvic acid.
Link: https://patents.google.com/patent/US20070212434A1/en?q=fulvic+acid&oq=fulvic+acid
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Conclusion: Oxifulvic acid inhibits inflammatory response of the human immune system to allergens.
Title: Pilot study to evaluate the safety and therapeutic efficacy of topical oxifulvic acid in atopic volunteers
Type of Document: Peer-reviewed journal article
Takeaway: In this double-blind cross-over study, 23 healthy volunteers allergic to grass or house dust mite allergen were recruited. Volunteers were randomized to either placebo, 1% hydrocortisone, 4.5 or 9% oxifulvic acid
creams. Creams were applied under occlusions 1 h prior to intradermal allergen challenge and every 8 h thereafter for 3 days (21-day intervals). Topically applied oxifulvic acid had no significant effect on any of the safety parameters and also did not induce sensitization when applied on the skin. Oxifulvic acid (4.5%) caused inhibition of the elicited inflammatory reaction at 15 min. These changes were similar to that caused by hydrocortisone.
Link: https://sci-hub.se/10.1002/ddr.10116
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Conclusion: Fulvic acid prevents allergy symptoms triggered via human immune cells.
Title: Inhibitory Effect of Fulvic Acid Extracted from Canadian Sphagnum Peat on Chemical Mediator Release by RBL-2H3 and KU812 Cells
Type of Document: Peer-reviewed journal article
Takeaway: Fulvic acid (FA) was extracted and purified from Canadian Sphagnum peat (CP-FA) also inhibited the histamine release from A23187 plus PMA- or compound 48/80-stimulated KU812 cells.
Link: https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/17485833/
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Conclusion: Fulvic acid stimulates the immune system to help defend the body from infections.
Title: Fulvic Acid – A Natural and Multifaceted Approach to the Management of Inflammatory Dermatosis
Type of Document: Review article
Takeaway: Fulvic acid stimulates the immune system to help defend the body from infections.
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Conclusion: Humic acids strengthen the immune system.
Title: Study of the Influence of Humic Acid Macromolecules on the Structure of Erythrocytes of Some Animals by the Method of Absorption
Type of Document: Peer-reviewed journal articles
Takeaway: Recently, an increase has been observed in the interest to the application of humic acids (HA) in medicine. These are the examples of HA effect on some vitally important properties of human organism. One of the most pronounced HA effects is strengthening of the general immune response. Humic compounds regulate the number of glycoproteins that affect the balance of Т- and В-lymphocytes. In addition, these activate the synthesis of interleukins 1 and 2 and the production of endogenous interferon and gamma-globulins which activates the oppressed functions of immune system.
Link: https://www.intechopen.com/chapters/66666
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Conclusion: Fulvic acid exerts an activating effect on the immune system.
Title: Characterization and Biological Activities of Humic Substances from Mumie
Type of Document: Peer-reviewed journal article
Takeaway: The results of our studies suggest that the activating effect of mumie on the immune system is caused in part by fulvic acid (FA) stimulation of macrophages and lymphocytes.
Link: https://sci-hub.se/10.1021/jf021101e
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Conclusion: Humic substances can activate infection-fighting cells of the human immune system called neutrophils.
Title: Humate-induced activation of human granulocytes
Type of Document: Peer-reviewed journal article
Takeaway: Results suggest that the low-molecular humic substances originating from decaying organic material contain chemical structures which can act as signals to change dormant human neutrophils into activated cells.
Link: https://sci-hub.se/https://link.springer.com/article/10.1007/BF02899524
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Conclusion: Naturally occurring humic acids can enhance immunity.
Title: Effects of humic acids in vitro
Type of Document: Peer-reviewed journal article
Takeaway: Results from in vitro study conducted with humic acids from the natural source showed potential of these substances as promising immunity enhancing agents.
Link: https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/21487922/