Conclusion: Anhydrofulvic acid shows antifungal activity against Candida utilis.
Title: Mode of action of anhydrofulvic acid against Candida utilis ATCC 42402 under acidic condition
Type of Document: Peer-reviewed journal article
Takeaway: The mode of action of anhydrofulvic acid against Candida utilis ATCC42402 was investigated under acidic conditions. Anhydrofulvic acid inhibited the incorporation of radioactive precursors into DNA, RNA, protein and lipid fractions. Although it did not induce leakage of intracellular materials from the treated cells, it had inhibitory effects on both endogenous and exogenous cellular respiration. Moreover, it inhibited mitochondrial respiration of Candida utilis ATCC42402 using both succinate and cytochrome c as respiratory substrates, but not using NADH. Unexpectedly, the inhibition against isolated mitochondria was observed at pH 7.0. These results suggested that the action site against the respiratory inhibition of anhydrofulvic acid might be involved in succinate dehydrogenase, complex II in the mitochondrial electron transport chain of the yeast cells. Judging from the inhibitory effect of anhydrofulvic acid on mitochondria detected at pH 7.0, it was postulated that the antifungal activity at a low pH level might depend on the elevation of drug permeability to the cell membrane under acidic conditions.
Link: https://pubmed.ncbi.nlm.nih.gov/10513842/
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Conclusion: Fulvic acid can be used as an antifungal agent to treat Candida infections.
Title: Fulvic acid and its use in the treatment of candida infections
Type of Document: Patent
Takeaway: This patent describes the use of fulvic acid, a salt, an ester or a derivative thereof in the manufacture of a medicament for treatment in humans and animals of candida infections.
Link: https://patents.google.com/patent/EP1700599B1/en
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Conclusion: Fulvic acids have antifungal and antibacterial properties.
Title: Preparation and investigation of fulvic acid and its metal derivative complexes with application
Type of Document: Peer-reviewed journal article
Takeaway: The antimicrobial activity test revealed that fulvic acid-metal complexes recorded an activity against Candida albicans fungi. In contrary, it was found that most compounds exhibit antibacterial activity against the other tested types of microbes, including Escherichia coli and Streptococcus pneumoniae.