Conclusion: Fulvic and humic acids may improve the biochemical generation of energy in the body.
Title: Effect of humic substances on mitochondrial respiration and oxidative phosphorylation
Type of Document: Peer-reviewed journal article
Takeaway: Fulvic and humic acids extracted from a podzol were shown to stimulate respiration in rat liver mitochondria, when present at concentrations of between 40 and 360 mg/L. Low molecular weight fractions induced a more significant increase in respiration than high molecular weight material. Humic substances, at concentrations of between 40 and 400 mg/L, normally also increased the efficiency of the process of oxidative phosphorylation in vitro, particularly after contact periods with the mitochondria of over 1 hour.
Link: https://sci-hub.hkvisa.net/10.1016/0048-9697(87)90521-3
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Conclusion: Humic and fulvic acid supplements increase energy and reduce fatigue.
Title: Mechanisms of Action of Humic Substances as Growth Promoters in Animals
Type of Document: Book chapter
Takeaway: In humans, HA and FA preparations are promoted as supplements to increase energy and to reduce fatigue. In a rodent model, a product containing 60–80% HS reversed the negative behavioral symptoms of depression and anxiety caused by chronic fatigue syndrome and also stabilized the HPA axis stress response by reversing the drop in corticosterone levels and adrenal gland weight; it was suggested that the effects of HS were partially due to the regulation of mitochondrial bioenergetics by increasing the activities of mitochondrial NADH dehydrogenase, succinate dehydrogenase, cytochrome oxidase, and ATP synthase.
Link: https://www.intechopen.com/online-first/82760
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Conclusion: Fulvic acid-containing herbal composition reduces fatigue.
Title: Anti-fatigue effect of OM-X, fermented plant extract with lactic acid bacteria and bifidobacterial: A randomized, placebo-controlled, double-blind, comparative study
Type of Document: Peer-reviewed journal article
Takeaway: In conclusion, we found out that the 12-week ingestion of OM-X made of fermented plant extract with LAB and bifidobacteria might ameliorate the feeling of fatigue for healthy people with temporary fatigue. Note that the test food, OM-X is made of the fermented extract, which consists of several kinds of Japanese plants with 12 kinds of LAB and bifidobacteria such as TH10. Fulvic acid, d-amino acids, l-amino acids, melanoidin, polyphenols, organic acids, fatty acids, vitamins, minerals, dietary fibers, oligosaccharides, LAB, and bifidobacteria are included in the Active.
Link: https://www.sciencedirect.com/science/article/pii/S1756464622002985
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Conclusion: Shilajit reduces fatigue symptoms in chronic fatigue syndrome.
Title: Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic–pituitary–adrenal axis and mitochondrial bioenergetics in rats
Type of Document: Peer-reviewed journal article
Takeaway: The results indicate that shilajit mitigates the effects of CFS in this model possibly through the modulation of HPA axis and preservation of mitochondrial function and integrity. The reversal of CFS-induced behavioral symptoms and mitochondrial bioenergetics by shilajit indicates mitochondria as a potential target for treatment of CFS.
Link: https://sci-hub.hkvisa.net/10.1016/j.jep.2012.06.002
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Conclusion: Shilajit helps reduce fatigue and tiredness.
Title: Shilajit: A panacea for high-altitude problems.
Type of Document: Peer-reviewed journal article
Takeaway: Shilajit actively takes part in the transportation of nutrients into deep tissues and helps to overcome tiredness, lethargy, and chronic fatigue.
Link: https://www.ncbi.nlm.nih.gov/pubmed/20532096
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Conclusion: Fulvic acid containing shilajit increases energy production in humans.
Title: Energy and Health Benefits of Shilajit
Type of Document: Book chapter
Takeaway: Subjects were given 200 mg processed shilajit once daily for 15 days. Treatment with shilajit significantly increased energy production and physical exercise. In addition, the energy production was confirmed based on increases in adenosine triphosphate (ATP), ATP/adenosine diphosphate (ADP) ratio, coenzyme Q10 (CoQ10), total adenine nucleotides, adenylate energy charge, and uric acid levels in whole blood.
Link: https://sci-hub.ru/https://www.sciencedirect.com/science/article/pii/B9780128054130000120
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Conclusion: Fulvic acid containing shilajit is known to enhance endurance and strength in humans.
Title: Selected herbals and human exercise performance
Type of Document: Review article
Takeaway: Shilajit (or mummio), which contains fulvic acid, has anti-stress properties and enhances endurance and strength. Eastern European weightlifters have been using mummio as part of an “herbal anabolic stack” to promote better strength, recovery, and muscular hypertrophy.
Link: https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/10919969/
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Conclusion: Fulvic acid containing shilajit helps retain muscular strength in humans.
Title: The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels
Type of Document: Journal article
Takeaway: The results of the present study demonstrated that 8 weeks of PrimaVie® Shilajit supplementation at 500 mg per day promoted the retention of maximal muscular strength following the fatiguing protocol and decreased baseline serum hydroxyproline, an indirect biomarker of collagen degradation and the integrity of connective tissue following high-intensity exercise. Thus, PrimaVie® Shilajit supplementation at 500 mg per day elicited favorable muscle and connective tissue adaptations.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364418/