Conclusion: Humic substances have anti-inflammatory properties.
Title: The Antiinflammatory Properties of Humic Substances: A Mini Review
Type of Document: Peer-reviewed journal article
Takeaway: Humic substances are effective in the suppression of delayed type hypersensitivity, rat paw oedema, a graft versus host reaction and contact hypersensitivity in rats. They reduce the C-reactive protein levels of patients suffering from osteoarthritis of the knee and the wheel and flare reaction of patients suffering from hay fever. They have also been described as cardioprotective and pro-angiogenic. Toxicity studies have indicated that potassium humate is safe in humans up to a daily dosage of 1 g/kg, whereas fulvic acid is safe in humans up to a daily dosage of 1.8 g per adult. The antiinflammatory action of potassium humate can be attributed to the inhibition of the release of inflammatory-related cytokines, an adhesion molecule, oxidants and components of the complement system.
Link: https://sci-hub.hkvisa.net/10.1002/ptr.5319
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Conclusion: Carbohydrate-derived fulvic acid has anti-inflammatory properties.
Title: Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid
Type of Document: Peer-reviewed journal article
Takeaway: The purpose of this research was to determine the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid (CHD-FA). No severe adverse events occurred, establishing that CHD-FA to be safe at doses up to 40 mL twice daily for a week and that at this dosage CHD-FA acts as an anti-inflammatory agent.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304339/
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Conclusion: Humic substances may enhance involuntary muscle activity and exhibit anti-inflammatory
Title: Dose-Dependent Effects of Different Humic Substances in Preclinical Test Systems
Type of Document: Peer-reviewed journal article
Takeaway: The results show for all applied test systems that humic substances (HS) acted in a dose-dependent manner. At low concentrations (1–10 microg/mL), they enhanced the spontaneous contractile activity of smooth muscles by stimulating alpha(2)-adrenoceptors and dopamine D2 receptors; at intermediate concentrations (10–250mg/mL), they inhibited TNF-alpha release; and at high concentrations (250–1,000 microg/mL), they acted as anticoagulants.
Link: https://sci-hub.hkvisa.net/https://link.springer.com/chapter/10.1007/978-94-007-5634-2_207