Conclusion: Fulvic acid may induce cancer cell death.
Title: Fulvic acid promotes extracellular anti-cancer mediators from RAW264.7 cells, causing to cancer cell death in vitro
Type of Document: Peer-reviewed journal article
Takeaway: Fulvic acid (FA) induces the generation of NO and iNOS in RAW 264.7 cells by inducing NF-κB activation. In addition, FA-stimulated culture media enhanced cell death in various human cancer cells such as Hep3B, LNCaP, and HL60. Taken together, FA most likely stimulates immune-modulating molecules such as NO and induces cancer cell apoptosis.
Link: https://fulvic.info//wp-content/uploads/2019/01/M-Cancer-cell-death-study1-RMIT-1-1.pdf
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Conclusion: Humic substances may be effective in cancer therapy.
Title: Humic Substances As A Potent Biomaterials For Therapeutic And Drug Delivery System – A Review
Type of Document: Peer-reviewed journal article
Takeaway: The researches on humic substances still have great relevance in drug formulation and drug delivery system. Based on the collective indication of the biochemical and molecular effects of humic substances may make them robust candidates for cancer therapy.
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Conclusion: Humic acids have anti-cancer and anti-aging properties and may help protect against toxicity caused by iron, lead, copper, and mycotoxins.
Title: Therapeutic Efficiency of Humic Acids in Intoxications
Type of Article: Review Article
Summary: Humic acids (HAs) possess antioxidant activity. This property also gives HAs their anti-cancer effect. Moreover, the administration of HAs can be useful as a supportive treatment alongside cancer chemotherapy, where it protects tissue cells around the application of chemotherapeutics and prevents (mitigates) oxidative damage to these cells. Antioxidant effects of HAs can also be beneficial in anti-aging therapy, lowering social stress, and promoting wound healing, as well as in protecting against iron-induced hepatotoxicity and cardiotoxicity. Additionally, HAs can protect against lead and copper poisoning, mycotoxins, and other toxicants.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143271/
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Conclusion: Fulvic acid-containing formulations may have anti-cancer properties.
Title: Nutritional supplement composition for treating coronavirus infections, cancer, ME, post viral & Chronic fatigue syndrome & neurodegeneration in an individual
Type of Document: Patent
Takeaway: A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising NMN, NAD, PQQ, CoQ10, piperine, vitamin B7, vitamin B9, and vitamin B12. Further disclosed is a chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Resveratol, Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion’s Mane Mushrooms, vitamin B1, vitamin B2, vitamin B5, vitamin B6, Piperine and Zinc Complex. Further disclosed is chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Alpha Lipoic Acid (ALA), Acetyl-L-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta Glucans, Epigallocatechin 3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (incl. Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine, piperine, and additionally, humic and fulvic acids in some embodiments.
Link: https://patents.google.com/patent/GB2596849A
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Conclusion: Fulvic acid may be able to kill liver cancer cells.
Title: Anti-Proliferative and Anticancer Properties of Fulvic Acid on Hepatic Cancer Cells
Type of Document: Peer-reviewed journal article
Takeaway: This study showed that fulvic acid (FA) has the anticancer properties by increasing apoptosis and via production of nitric acid and reactive oxygen species. Our study demonstrated that fulvic acid may be useful in liver cancer and related disorders.
Link: https://sci-hub.se/https://www.jcehepatology.com/article/S0973-6883(15)00118-8/fulltext
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Conclusion: Humic substances may activate the immune system, reduce oxidative stress and kill liver cancer cells.
Title: Humic substances as an environmental- friendly organic wastes potentially help as natural anti-virus to inhibit COVID-19
Type of Document: Peer-reviewed journal article
Takeaway: The information gathered in this review indicates that humic substances (HS) can act as an immune modulator, influence the redox state, and potentially affect gut health. HS is shown to decrease pro-inflammatory markers but also activate the immune system to inhibit COVID-19. It is shown to reduce oxidative stress and even induce apoptosis in hepatic cancer lines.
Link: www.sciencearchives.org/wp-content/uploads/2020/09/Science-Archives-2020-Vol.-1-2-53-60.pdf
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Conclusion: Shilajit may induce the death of liver cancer cells.
Title: Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
Type of Document: Peer-reviewed journal article
Takeaway: The data clearly indicate that Mineral Pitch or Shilajit induced apoptosis via the production of ROS, and inhibited proliferation by inducing miRNA-22 and inhibiting miRNA-21 in Huh-7 cells.
Link: https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1131-z
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Conclusion: Fulvic acid may hinder the progress of colorectal cancer.
Title: Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells
Type of Document: Peer-reviewed journal article
Takeaway: Resistin may play a role in colorectal cancer (CRC) development. Fulvic acid (FA), a class of humic substances, possesses pharmacological properties. Co-treating cells with both FA and resistin revealed that FA significantly attenuated the resistin-increased NF-κB activation and ICAM-1/VCAM-1 expression and the consequent adhesion of HCT-116 cells to HUVECs. These results demonstrate the role of resistin in promoting HCT-116 cell adhesion to HUVECs and indicate that FA might be a potential candidate for the inhibition of the endothelial adhesion of CRC in response to resistin.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691117/
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Conclusion: Shilajit has anti-inflammatory, anti-oxidative, anti-cancer, and immunomodulatory properties.
Title: Shilajit in Cancer Treatment: Probable Mode of Action
Type of Document: Peer-reviewed journal article
Takeaway: Humic and fulvic acid have been reported to possess cancer preventive properties. It has been shown that these compounds can inhibit mutagenesis and have free radicals scavenging, photo-protecting, anti-inflammatory and toxic compound removing properties that can inhibit cancer development. Shilajit is a non-expensive, non-toxic compound which can be taken orally. Therefore, it is rational that future clinical studies should focus on examining the efficacy of Shilajit and its active constituents in cancer prevention as an alternative pharmacological agent. In this review, we address the use of Shilajit and its constituents for the prevention and management of cancer. Shilajit is one such compound, which has been used in Ayurveda for centuries. The humic compounds of Shilajit can be a potential cancer preventive agent. Anti-inflammatory, anti-oxidative, anti-mutagenic, immunomodulatory and several other effects of Shilajit have been already reported.
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Conclusion: Shilajit may be useful in cancer treatment and prevention.
Title: Shilajit: A Humic cure for Cancer
Type of Document: Peer-reviewed journal article
Takeaway: Shilajit and HA possess anti-inflammatory, antioxidant, antimutagenic, antitoxic, antiviral, heavy metal chelating, antitumor, apoptotic and photo-protective properties. These properties make Shilajit useful agents for cancer therapy and prevention. In addition, Shilajit has no reported side effects and can be administered as a nutritive and rejuvenating tonic and combats age related problems.
Link: https://altermed.com.ua/pdf/shilajit-a-panacea-for-cancer.pdf
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Conclusion: Fulvic acid may inhibit the multiplication of cancer cells and may even cause cancer cell death.
Title: Effects of Fulvic Acid on Different Cancer Cell Lines
Type of Document: Peer-reviewed journal article
Takeaway: Hep3B, HT29 and PC3 cells were treated different concentrations fulvic-acid for 48 and 72 h and cell proliferation was performed MTT test. Fulvic-acid inhibited the proliferation of all the cell lines used in this study determined by MTT analysis. Specifically, Hep3B cells were found to be most sensitive for 48-hour application with 1.58–2.43 μg/μL IC50 value. Additionally, fulvic-acid significantly upregulated the apoptotic genes at mRNA levels compared to non-treated control group.
Link: https://doi.org/10.3390/proceedings1101031
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Conclusion: Humic acid may be able to kill breast cancer cells.
Title: The Cytotoxic Effects of Humic Acid on Human Breast Cancer Cells
Type of Document: Peer-reviewed journal article
Takeaway: Humic acid (HA) induces apoptosis and has various pharmacological properties including anti-inflammatory and anti-proliferative effects. In our study, we examined the cytotoxic effects of HA at concentrations of 5, 10, 20, 50 and 100 μg/mL in human breast adenocarcinoma MCF-7 cell line for 24 and 48 h. By using MTT method, it has been found out that HA 100 μg/mL had cytotoxic effect on human breast adenocarcinoma MCF-7 cell line at both 24 and 48 h; also found out that the effective dose of HA at the same time (24 and 48 h) was 50 μg/mL.
Link: https://doi.org/10.3390/proceedings2251565
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Conclusion: Fulvic acid may hinder the progress of colorectal cancer.
Title: Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells
Type of Document: Peer-reviewed journal article
Takeaway: Fulvic acid might be a potential candidate for the inhibition of the endothelial adhesion of colorectal cancer in response to resistin, a serum compound that plays an important role in the development of this cancer.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691117/
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Conclusion: Humic acid may enhance the anti-cancer activity of arsenic trioxide in cervical cancer.
Title: Humic acid enhances the cytotoxic effects of arsenic trioxide on human cervical cancer cells
Type of Document: Peer-reviewed journal article
Takeaway: Our results shown both As2O3 and HA-induced inhibition of cell growth, most likely by ROS-mediated cell damage and activation of the apoptosis pathway, and HA enhanced the anti-proliferative action of As2O3 in HeLa and SiHa cells, which reduced the LC50 about 57.62 or 73.52% (300 μg HA/mL) to 83.67 or 79.03% (500 μg HA/mL), respectively. This study is relevant to the development of chemotherapeutic approaches using As2O3 in treating human cervical cancer.
Link: https://sci-hub.hkvisa.net/10.1016/j.etap.2009.11.009
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Conclusion: Fulvic acid-containing nutritional supplements can help treat cancer.
Title: Healthful supplement food
Type of Document: Patent
Takeaway: The supplement foods described herein have no negative side effects and can optimize health of animals, including humans, who receive them. The supplemental food contains a number of nutrients including at least four of the following: amino acid blend, Fulvic-humic acids, multi-minerals, glycerin, phosphatidylinositol, sesquiterpene alkaloids, terpenes, medium-chain triglycerides (MCTs), coconut oil, whole plant matter, plant seeds, mushrooms, seaweeds, kelp, and flavoring agents. The supplement foods have surprising benefits, such as reducing the incidence and/or severity of disease relative to an animal (or human) who does not receive the supplements. Humans and animals that receive the supplements can exhibit resistance to disease and improved immune responses. Humans and animals that receive the supplements can have reduced pain, disease improvement, more energy, improved sleep patterns, increased activity levels, reduced extremity numbness, improved digestion, fewer headaches, reduced symptoms, fewer tumors, fewer cancer cells, and/or fewer seizures, compared to their own experience prior to taking the supplements.
Link: https://patents.google.com/patent/US20200000136A1/
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Conclusion: Modified fulvic acid may act as an anti-cancer drug.
Title: Application of modified fulvic acid in preparation of antitumor drugs
Type of Document: Patent
Takeaway: The invention discloses application of modified fulvic acid in preparation of antitumor drugs. A preparation method of the modified fulvic acid comprises the following steps: (1) directionally degrading a raw material containing fulvic acid or fulvic acid in water through HNO3 and H2SO4 to obtain a fulvic acid degradation product; and (2) under a microwave condition, carrying out reaction between the fulvic acid degradation product obtained from the step (1) and kojic acid or extract containing kojic acid to obtain the modified fulvic acid. The application disclosed by the invention, compared to the existing treatment medicines, has the advantages in following three aspects: 1) the modified fulvic acid can be extracted from peat resource, thus realizing full use of resource and protecting environment; 2) the prepared antitumor drugs are rich in raw medicine resource, and although being same with the existing treatment medicines in curative effect, are higher in cost performance; and 3) the antitumor drugs, compared to other Western medicines, are good in curative effect and less in side reaction. The modified fulvic acid preparation disclosed by the invention is good in both social and economic benefits.
Link: https://patents.google.com/patent/CN103720716A/
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Conclusion: Fulvic acid can help treat skin cancer (melanoma).
Title: Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid: BAX/BCL-2 and Tyr genes expression and evaluation of nanomechanical properties in A375 human melanoma cell line
Type of Document: Peer-reviewed journal article
Takeaway: These results exhibited that fulvic acid (FA) and humic acid (HA) possess pro-apoptotic effects through increasing the BAX/ BCL-2 expression in A375 (human melanoma) cells. These molecular reports were confirmed by cellular nanomechanical assessments using AFM and flow cytometry. In addition, HA and FA inhibited melanogenesis by decreasing the expression of the Tyr gene. It is worthwhile to note that, HA and FA can be regarded to design new anti-cancer and anti-melanogenesis products.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150800/
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Conclusion: Fulvic acid may be effective against squamous cell carcinoma (oral cancer).
Title: Evaluating the Effect of Fulvic Acid on Oral Bacteria and Cancerous Oral Cells
Type of Document: Conference poster
Takeaway: To evaluate the effect of fulvic acid on human squamous cell carcinoma (SCC-25) cells, six-well plates seeded with SCC-25 cells were exposed to different concentrations of fulvic acid for 72 hours. The cytotoxicity and cell proliferation were measured. It was determined that fulvic acid inhibits the growth of SCC-25 cells at concentrations of fulvic acid above 2% (volume %). The suppressive mechanisms observed by fulvic acid on both S. mutans and SCC-25 cells could improve overall oral health.
Link: https://scholarworks.iupui.edu/handle/1805/5369
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Conclusion: Fulvic acid can kill human breast cancer cells.
Title: A New Insight Into the Anti Proliferative and Apoptotic Effects of Fulvic and Humic Acids as Bio Product of Humus on Breast Cancer Cells, Optimized by Response Surface Methodology
Type of Document: Peer-reviewed journal article
Takeaway: Our results showed that humic acid (HA) and fulvic acid (FA) induced apoptosis, reduced cell viability and gene expression in the cured MCF7 (human breast cancer) cells.
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Conclusion: Fulvic acid compositions absorbed through the skin may help treat cancer.
Title: Special preparation for treating cancer recovery by mineral spring medicinal bath
Type of Document: Patent
Takeaway: The present invention relates to special preparation for mineral spring medicinal bath to treat cancer, and the mineral spring medicinal bath is one combination of traditional mineral spring treatment and traditional Chinese medicine fumigating and washing treatment. Trace elements essential for the patient of cancer and the decoction of Chinese medicine with the functions of resisting cancer and strengthening resistance are set inside bath tub and maintained at temperature over 34 deg.c for the patient to soak in and his skin to absorb the effective components to speed recovery from cancer. The method of treating internal disease from outside is suitable for treating various cancers of lung, stomach, liver, kidney, large intestine, womb, etc. and is safe, stable and convenient. It may be matched with pharmacotherapy, radiotherapy and chemotherapy to raise treating effect and reduce toxic side effect. Chemical content of this bath is selenium (sodium selenite), molybdenum (sodium molybdate), germanium (fulvic acid), zinc (zinc sulfate), silicon (sodium silicate), iodine (sodium iodide), iron (ferrous sulfate), manganese (potassium permanganate).
Link: https://patents.google.com/patent/CN1531937A/
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Conclusion: Fulvic acid derivatives may have anti-cancer properties.
Title: Preparation facilities of anti -ageing medicines and health protection article of anti -cancer anticancer
Type of Document: Patent
Takeaway: The patent discloses a high-purity active ingredient mixture comprising of xanthohumol, mannan, selenium malt seedling, domestic fungus, bluish dogbane tea, and mulberry huang for anti -ageing, anti-muscular atrophy and anticancer activities. In the preparation step, fulvic acid, fructus hordei germinatus, brewer’s yeast are sent into a biological extraction reactor through an intelligent feeder for producing xanthohumol (fulvic acid is 30-99%:1-70% relative to the ratio of the mixture of fructus hordei germinatus and brewer’s yeast).
Link: https://patents.google.com/patent/CN204949483U/
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Conclusion: Fulvic acid compositions may be able to treat cancer.
Title: Solid pharmaceutical compositions and processes for their production
Type of Document: Patent
Takeaway: The present invention relates to a novel solid pharmaceutical composition, containing 1% (w/w) sodium fulvic acid along with other components, and a method of mass producing the same. The invention also provides a method of treating cancer using such pharmaceutical compositions.
Link: https://patents.google.com/patent/TWI597073B/
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Conclusion: Fulvic acid-containing formulations may have anti-cancer properties.
Title: Nutritional supplement composition for treating coronavirus infections, cancer, ME, post viral & Chronic fatigue syndrome & neurodegeneration in an individual
Type of Document: Patent
Takeaway: A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising NMN, NAD, PQQ, CoQ10, piperine, vitamin B7, vitamin B9, and vitamin B12. Further disclosed is a chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Resveratol, Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion’s Mane Mushrooms, vitamin B1, vitamin B2, vitamin B5, vitamin B6, Piperine and Zinc Complex. Further disclosed is chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Alpha Lipoic Acid (ALA), Acetyl-L-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta Glucans, Epigallocatechin 3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (incl. Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine, piperine, and additionally, humic and fulvic acids in some embodiments.
Link: https://patents.google.com/patent/GB2596849A
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Conclusion: Fulvic acid-containing formulations may have anti-cancer properties.
Title: Compositions and methods for treating cellular proliferation disorders
Type of Document: Patent
Takeaway: This patent describes a method for treating a person suffering from a cellular proliferation disorder (including cancer and some autoimmune disorders) characterized by an increased voltage-gated ion-channel uptake, comprising: administering to the person a composition comprised of a compound selected from the group consisting of matrine, oxymatrine, artemisinin, agmatine, and vinpocetine. The method can further comprise of co-administering an enhancing compound selected from the group consisting of hydroxycitric acid, a sodium or potassium salt of hydroxycitric acid, fumaric acid, an ester of fumaric acid, fulvic acid, and a salt of fulvic acid.
Link: https://patents.google.com/patent/WO2005044272A1/
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Conclusion: Humic substances have anti-cancer activity for Leukemia.
Title: Antitumor effect of humus extract on murine transplantable L1210 leukemia
Type of Document: Peer-reviewed journal article
Takeaway: Humic substances are formed during the decomposition of organic matter in humus that is found in many natural environments in which organic materials and microorganisms have been present. In the present study, humus extract exhibited antitumor effect on L1210 tumor development in isogeneic DBA/2 mice with the delay of tumor formation and a significant smaller tumor mass that infer a significant increase of life span of mice. The antitumor effect was not due to direct killing of L1210 or induction of apoptosis in tumor cells by humus extract.