Conclusion: Humic substances can activate the immune system to inhibit COVID-19
Title: Humic substances as an environmental- friendly organic wastes potentially help as natural anti-virus to inhibit COVID-19
Type of Document: Peer-reviewed journal article
Takeaway: The information gathered in this review indicates that HS can act as an immune modulator, influence the redox state, and potentially affect gut health. HS is shown to decrease pro-inflammatory markers but also activate the immune system to inhibited COVID-19. It is shown to reduce oxidative stress and even induce apoptosis in hepatic cancer lines. HS is shown to also influence the micro-biome and possibly improve gut function. This will help make conclusive statements regarding HS function and its influence on immune-related diseases.
Link: http://dx.doi.org/10.47587/SA.2020.1202
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Conclusion: Fulvic acid-containing humic substance mixtures may possess virus destroying activity against SARS-CoV-2 virus (coronavirus).
Title: Nanodispersions of Polyelectrolytes Based on Humic Substances: Isolation, Physico-Chemical Characterization and Evaluation of Biological Activity
Type of Document: Peer-reviewed journal article
Takeaway: The results of our research suggest that the chemical structure of natural humus polyelectrolytes is due to the stabilizing interaction of macromolecules with nanoparticles of lyophobic sols–metals with the formation of complexes of the macromolecule-nanoparticle type. The intensity of the fluorescence signal showed that in addition to the organic structure of the non-stoichiometric composition and irregular heterogeneous structure with numerous functional groups, occluded metal nanoparticles are present in the components of humic acids. Polyelectrolytes modified in this way are a unique transport object for medicinal substances. In addition, our studies have demonstrated the possibility of independent binding of naturally branched polyelectrolyte complexes of humic substances with SARS-CoV-2 S-protein in vitro. A study of the EHS effect on the SARS-CoV-2 virus infectious titer in the Vero E6 cell showed the effective against virus both in the virucidal scheme (the SI is 11.90–22.43) and treatment/prevention scheme (the SI is 34.85–57.33). We suppose that the proposed approach will be useful in laboratory and clinical settings for the development of standard quality control protocols, as well as the creation of a promising standardized drug with virucidal treatments for the prevention of coronavirus infection.
Link: https://www.mdpi.com/1999-4923/13/11/1954/htm
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Conclusion: The immune-boosting and antiviral activities of fulvic acid may make it effective against SARS-CoV-2 virus (coronavirus).
Title: Prevention of Viral Effect and Enhancement of Immune System with the help of Herbal Plants and Himalayan Crude Drugs in SAR-COV-2 Patient; A Review
Type of Document: Review article
Takeaway: Fulvic acid, humic acid, hippuric acid, and benzopyrones have immune-boosting as well as antiviral activity which can be their possible mechanism of action against SARS-CoV-2.
Link: https://dergipark.org.tr/en/pub/cupmap/issue/62212/948975
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Conclusion: Fulvic acid-containing compositions may be effective against COVID-19.
Title: THE PANDEMIC- COVID 19- A RACE OF PHARMACEUTICALS
Type of Document: Review article
Takeaway: Compositions with fulvic acid, humic acid, hippuric acid, and benzopyrones have been used against COVID-19 as a natural treatment strategy.
Link: http://plantarchives.org/SPECIAL%20ISSUE%2021-1/346%20(2098-2104).pdf
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Conclusion: Fulvic acid could have potential as a drug against COVID-19.
Title: Interaction of Drug Candidates with Various SARS-CoV-2 Receptors: An in Silico Study to Combat COVID-19
Type of Document: Peer-reviewed journal article
Takeaway: In this work, molecular docking was used to study (in silico) the interaction of 24 ligands, divided into four groups, with four SARS-CoV-2 receptors, Nsp9 replicase, main protease (Mpro), NSP15 endoribonuclease, and spike protein (S-protein) interacting with human ACE2. The results showed that the antimalarial drug Metaquine and anti-HIV antiretroviral Saquinavir interacted with all the studied receptors, indicating that they are potential candidates for multitarget drugs for COVID-19. Fulvic Acid also showed binding energy equal to −7 kcal/mol with Receptors 2 and 4, two of the SARS-CoV-2 receptors.
Link: https://pubs.acs.org/doi/full/10.1021/acs.jproteome.0c00327
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Conclusion: Fulvic acid can be a potential inhibitor of the SARS-CoV-2 virus (coronavirus).
Title: Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial Sources
Type of Document: Review article
Takeaway: The SARS-CoV-2 viral proteases, 3-chymotrypsin-like protease (3CLpro) and papain-like cysteine protease (PLpro), have become the promising target to study due to their essential functions in spreading the virus by RNA transcription, translation, protein synthesis, processing and modification, virus replication, and infection of the host. Thus, we have compiled various reported literature in detail on the structures, functions of the SARS-CoV-2 proteases, and potential inhibitors from microbial sources as assistance to other researchers working with COVID-19. Fulvic acid is also a potential inhibitor from microbial sources for SARS-CoV-2 proteases.
Link: https://www.mdpi.com/2076-2607/9/12/2481/pdf?version=1638276907
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Conclusion: Fulvic acid has an antiviral effect against COVID-19-causing SARS-CoV-2 virus.
Title: A Comprehensive Biological and Physico-Chemical Characterization of Humic and Fulvic Acids Nanoparticles as a Perspective Drug
Type of Document: Journal article
Takeaway: The results of the study of the antiviral activity of extracted humic substances (EHS) and fulvic acid (FA) showed that the study objects in the culture of Vero-E6 cells, in doses non-toxic to cells, suppress the reproduction of the SARS-CoV-2 virus both in the study of the virucidal effect and in the study of the antiviral activity according to the therapeutic and prophylactic model scheme of injection. The results obtained suggest that standardized drugs based on humic acids may open up new perspectives in their biomedical application as antiviral drugs.
Link: https://www.preprints.org/manuscript/202106.0245/v1
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Conclusion: Fulvic acid-containing formulations may be effective in treating COVID-19.
Title: Nutritional supplement composition for treating coronavirus infections, cancer, ME, post viral & Chronic fatigue syndrome & neurodegeneration in an individual
Type of Document: Patent
Takeaway: The present invention discloses a chemo-preventative and cytotoxic formulation or composition is effective in treating coronavirus and other infections, cancer, PVLS/M1E/CES, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual. In one embodiment, the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) In one embodiment, the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) in the amount of about 25 mg to 250 mg. In one embodiment, the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) in the amount of about 100 mg.
Link: https://patents.google.com/patent/GB2596849A/
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Conclusion: Fulvic acid-supplemented intranasal iodine drops may be effective in inactivating SARS-CoV-2 virus (coronavirus) and preventing its transmission.
Title: In Vitro Efficacy of “Essential Iodine Drops” Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)
Type of Document: Journal article
Takeaway: This study evaluated the virucidal activity of the aqueous solution of Iodine-V (a clathrate complex formed by elemental iodine and fulvic acid) as in Essential Iodine Drops (EID) with 200 μg elemental iodine/ml content against SARS-CoV-2 to ascertain whether it is a better alternative to PVP-I. Substantial reductions in log reduction value (LRV) by Iodine-V in EID confirmed the activity of EID against SARS-CoV-2 in vitro, demonstrating that Iodine-V in EID is effective at inactivating the virus in vitro and therefore suggesting its potential application intranasally to reduce SARS-CoV-2 transmission from known or suspected COVID-19 patients.
Link: https://www.biorxiv.org/content/10.1101/2020.11.07.370726v1.abstract
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Conclusion: Fulvic acid-containing natural formulations may be effective in treating COVID-19.
Title: Protection against coronavirus infection by extracts and extract components
Type of Document: Patent
Takeaway: This invention relates to methods of treating, preventing, and protecting against viral infection including coronavirus infection such as COVID-19 with natural extracts and/or their components. The methods include administering plant and/or herbo-mineral extracts such as extracts of Shilajit, Withania somnifera, Asparagus racemosus, Terminaha chebula, Terminaha bellirica, Phyllanthus emblica, Azadirachta indica, and/or a trivalent chromium complex with extracts of P. emblica and Shilajit; and also administering extract components such as 3,8-dihydroxy-6H-benzo[c]chromen-6-one and 3-hydroxy-6H-benzo[c]chromen-6-one. In an embodiment, a Shilajit composition of this invention contains not less than 50% w/w of fulvic acids with DBP core nucleus and not less than 10.3% w/w of free dibenzo-α-pyrones and dibenzo-α-pyrone chromoproteins (DCPs) combined. Dibenzo-α-pyrones are also known as Urolithins, for example Urolithin A and Urolithin B. In an embodiment, PrimaVie® as a composition of this invention is a standardized aqueous extract containing 56-63% fulvic acids with a dibenzo pyrone core nucleus and 12-18% of free dibenzo-α-pyrones and dibenzo-α-pyrones conjugated with chromoproteins combined.
Link: https://patents.google.com/patent/US20220054575A1
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Conclusion: Fulvic acid-containing formulations may be effective in preventing the cytokine storm that occurs in COVID-19.
Title: Reduction of cytokine storm and pathological inflammation including caused by coronavirus using sphagnum and extracts thereof
Type of Document: Patent
Takeaway: In some embodiments, the methods and compositions encompassed herein are used to treat viral infections, including coronavirus infections (such as SARS-CoV-2), or symptoms associated with such infections. Certain embodiments comprise methods and compositions for preventing lung injury of any kind in an individual. The disclosure encompasses methods and compositions for stimulating the production of one or more growth factors, including keratinocyte growth factor (KGF), in an individual. In some embodiments, the issue of cytokine storm, as well as lung protection from the cytokine storm, is addressed by using humic acid, fulvic acid and/or various components of Sphagnum.